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  • Robert Preidt
  • Posted December 20, 2021

Scientists Find Clue to Links Between Autism, Epilepsy

Kids with autism have low levels of a protein that quiets overactive brain cells, which may explain why so many have epilepsy, according to a new study.

Because the protein can be detected in cerebrospinal fluid, it may have promise as a marker to diagnose autism and as a potential treatment target for the epilepsy that sometimes accompanies it, according to Northwestern University researchers.

The protein pinpointed in this study -- called CNTNAP2, or "catnap2" -- is produced by the brain cells when they become overactive. Because the brains of kids with autism and epilepsy don't have enough of it, their brains don't calm down, which leads to seizures, the study authors explained.

"We can replace CNTNAP2," said lead study author Peter Penzes, director of the Center for Autism and Neurodevelopment at Northwestern's Feinberg School of Medicine, in Chicago. "We can make it in a test tube and should be able [to] inject it into children's spinal fluid, which will go back into their brain."

For the study, the researchers analyzed cerebrospinal fluid from people with autism and epilepsy, and from mice. Levels of the protein in cerebrospinal fluid help determine levels in the brain.

The findings, published online Dec. 17 in the journal Neuron, could lead to new treatments, the study authors suggested in a university news release.

Penzes and his team are now conducting preclinical research on the injection technique.

While cerebrospinal fluid from patients with Alzheimer's and Parkinson's has been analyzed to help diagnose disease and assess response to treatment, the researchers said this is the first such study in people with autism.

In the United States, autism affects one in 58 children, and 30% to 50% of them also have epilepsy.

More information

The Autism Research Institute has more on autism and seizures.

SOURCE: Northwestern University, news release, Dec. 17, 2021

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